The PRO-PD was created because other scales do not permit this type of analysis. The PRO-PD is a patient-centered, continuous measure of disease severity that is stratifiable by symptom and correlates with quality of life and existing scales for PD severity (e.g. UPDRS, HY).[Mischley LK, 2017] Lower Scores are Better.
We surveyed over a thousand indiviuduals with PD and asked them to describe their symptoms. The most common symptoms were fatigue, impaired handwriting, loss of smell, memory impairment, and muscle pain.
Disease modification is only possible if we have a way of measure it. The symptoms of parkinsonism come on slowly, the fluctuate, and are often vague and difficult to rate.
Reversal= PRO-PD Score goes down, negative slope.
Stabilization: PRO-PD Score unchanged.
Progression: PRO-PD Score increases over time.
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DBA NeurRx SPC.